ALPHA-GAL INFORMATION

A project of the Alpha-gal Syndrome              Awareness Campaign

Alpha-gal Syndrome

The Epidemic You’ve Never Heard of

Alpha-gal syndrome (AGS), or mammalian meat allergy,  is a tick-induced allergy to galactose-α-1,3-galactose. This sugar, commonly known as alpha-gal, is found in non-primate mammals and foods, medications, and other products with ingredients derived from mammals. Reactions, which can be life-threatening, may be immediate, as in the case of injected drugs, or delayed from 2 to 10 hours, as is typical after the consumption of mammal-derived foods. 

In the U.S., the
lone star tick
is thought to be the primary vector of sensitization.

Have you been bitten by a tick?

Do you get sick in the middle of the night after eating red meat?

Do you have unexplained anaphylactic reactions, hives, GI issues, or arthritis?

You may have alpha-gal syndrome.

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What is Alpha-gal Syndrome?

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Symptoms

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Diagnosis and Testing

Expert Scott Commins Explains Alpha-gal Syndrome

Fast facts about
alpha-gal syndrome

 

“…in the southeastern United States, approximately 3% of the general population exhibits anaphylaxis after consumption of mammalian meat.”

John Bianchi

“In certain geographic areas and in populations with high tick exposure, the level of sensitization can be 15-35% but this does not represent clinical AGS, which appears to occur in 1-8% of sensitized individuals.”

Scott P. Commins, MD, PhD

“In geographic areas where tick bites are common, AGS is likely under- recognized and under-diagnosed. We suggest testing for alpha-gal IgE in tick-endemic areas as part of the evaluation for cases of idiopathic anaphylaxis, recurrent urticaria and/or angioedema, as well as recurrent, episodic gastrointestinal cramping of unestablished cause.”

Scott P. Commins, MD, PhD

#1

trigger of anaphylaxis in adults*

#1

cause of adult-onset allergy*

Up to 3%

of some populations*

*most of the southeastern U.S. and other populations with high tick exposure, including areas of the Midwest and much of the eastern U.S.

15-35%

of the population in the southern U.S. and large areas of the Midwest and eastern U.S. is sensitized to alpha-gal

Over 34,000

The number of Americans diagnosed has risen from 12 in 2009 to over 34,000 in 2019. It is estimated that there may be a million or more undiagnosed cases in the U.S. alone.

3-8 hours

typical delay of reactions after exposure

Up to 60%

of cases have anaphylactic reactions

30-40%

of cases have cardiac symptoms

Up to 20%

of cases have GI symptoms alone

More than 20,000

drugs, vaccines and medical products contain mammalian byproducts

Hundreds

of mammalian byproducts with obscure names like oleic acid are added to foods without being labeled as derived from mammals

7 years

average time to diagnosis due to lack of physician awareness

A reference section with links to the studies from which these numbers were drawn in is development. In the meantime, please feel free to contact us at alphagalinformation@gmail.com with any questions. We would be happy to provide you with more information.

Newly diagnosed? Start here!

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What Do My Test Results Mean?

Management of Alpha-gal Syndrome

Alpha-gal Tolerance Levels

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What Does AGS Make You Allergic To?

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Checklist for the Newly Diagnosed

Avoiding Additional Tick Bites

GET HELP

Make an Appointment with an Expert

Find a Support Group

Patient Recommended Physicians

Find Someone Local to Talk To

LEARN MORE

Where does alpha-gal syndrome occur?

Research

Help Find a Cure

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All the information on alphagalinformation.org is provided in good faith, but we, the creators and authors of the Alpha-gal Information website offer no representation or warranty, explicit or  implied, of the accuracy, adequacy, validity, reliability, availability, or completeness of any information on this site. Under no circumstances should we have any liability for any loss or damage incurred by you as a result of relying on information provided here. We are not physicians or medical professionals, researchers, or experts of any kind. Information provided in this website may contain errors and should be confirmed by a physician. Information provided here is not medical advice. It should not be relied upon for decisions about diagnosis, treatment, diet, food choice, nutrition, or any other health or medical decisions. For advice about health or medical decisions including, but not limited to, diagnosis, treatment, diet, and health care consult a physician.
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DISCLAIMER:

 All the information on alphagalinformation.org (“here” “this site”) is provided in good faith, but we, the creators and authors of the Alpha-gal Information website (“we” “us” or “our”) offer no representation or warranty, explicit or  implied, of the accuracy, adequacy, validity, reliability, availability, or completeness of any information on this site. Under no circumstances should we have any liability for any loss or damage incurred by you as a result of relying on information provided here. The user assumes all risk of using information provided here.

We are not physicians or medical professionals, medical or scientific researchers, or experts of any kind. We are laymen with alpha-gal syndrome with no medical or scientific expertise. The information provided by us on alphagalinformation.org  is provided for general informational purposes only. It may contain errors and should be confirmed by a physician. Information provided here is not medical advice and is not a substitute for the advice of a physician or other medical professional. It should not be relied upon for decisions about diagnosis, treatment, diet, food choice, nutrition, or any other health or medical decisions. For advice about making medical and health-related decisions, consult a physician.  

Alphagalinformation.org may contain links to other websites, embedded information from other websites, links to apps, or other sources of information belonging to or originating with third parties. We do not investigate, monitor, or evaluate information provided by external links or embedded third party features for accuracy, adequacy, validity, reliability, availability, or completeness. We do not warrant, endorse, or guarantee the accuracy of such information. We will not be a party to or in any way responsible for monitoring any transaction between you and any third-party provider of products, services, or information. Under no circumstances should we have any liability for any loss or damage incurred by you as a result of relying on third party information provided here. The user assumes all risk of using information provided here.

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